Table 3.
Skeletal muscle properties of patients with mitochondrial myopathy (n = 6) and healthy controls (n = 8)
| Patients | Controls | P-value | |
|---|---|---|---|
| Type I fibers (%) | 34.8 ± 3.6 | 55.7 ± 5.9 | < 0.001 |
| Type II fibers (%) | 65.2 ± 3.6 | 44.3 ± 5.9 | < 0.001 |
| CSA total (μm2) | 3,438 ± 915 | 4,698 ± 1,328 | 0.070 |
| CSA type I fibers (μm2) | 3991 ± 1211 | 5234 ± 1566 | 0.133 |
| CSA type II fibers (μm2) | 3,178 ± 852 | 4,359 ± 1,592 | 0.127 |
| MitoVD (%) | 4.0 ± 0.5 | 5.1 ± 0.8 | < 0.05 |
| IMFVD (%) | 3.4 ± 0.4 | 4.1 ± 0.5 | < 0.05 |
| SSVD (%) | 0.6 ± 0.3 | 1.0 ± 0.5 | 0.118 |
| LDVD (%) | 0.4 ± 0.1 | 0.4 ± 0.3 | 0.660 |
Values are represented as means ± SD. CSA cross sectional area; IMF VD intermyofibrilar mitochondrial volume density, LD VD lipid droplet volume density, Mito VD mitochondrial volume density, SS VD subsarcolemmal mitochondrial volume density