Table 3.

Univariate and multivariate regression models of factors predicting adverse pathologic outcomes in men undergoing radical prostatectomy at University of Pennsylvania, 1990–2012

Univariate analysis	OR	95 % CI	p value
Age	1	0.98 to 1.03	0.80
Racea
White	1	Reference
African-American/Black	1.21	0.83 to 1.77	0.32
Serum PSA	1.08	1.05 to 1.11	<0.001
Clinical stagea
T1c	1	Reference
T2a	1.05	0.64 to 1.72	0.85
T2b	3.00	1.11 to 8.17	0.03
> T2c	2.58	0.97 to 6.85	0.06
Year of Prostatectomy	0.97	0.94 to 1.00	0.05
Clinical Gleason scorea
≤ 6	1	Reference
7	2.21	1.48 to 3.29	<0.001
≥ 8	5.06	3.03 to 8.43	<0.001
Body mass index, categoricala
< 25 kg/m2	1	Reference
25 kg/m2 to <30 kg/m2	1.48	0.86 to 2.53	0.02
≥ 30 kg/m2	2.20	1.27 to 3.81	0.005
Multivariate analysis
Age	1	0.97 to 1.03	0.74
Racea
White	1	Reference
African-American/Black	0.81	0.50 to 1.32	0.40
Serum PSA	1.12	1.08 to 1.17	<0.001
Clinical stagea
T1c	1	Reference
T2a	1.24	0.72 to 2.14	0.43
T2b	2.28	0.70 to 7.38	0.17
> T2c	1.21	0.37 to 4.03	0.75
Year of Prostatectomy	0.99	0.95 to 1.04	0.69
Clinical Gleason scorea
≤ 6	1	Reference
7	2.01	1.24 to 3.25	0.005
≥ 8	5.97	3.02 to 11.78	<0.001
Body mass index, categoricala
< 25 kg/m 2	1	Reference
25 kg/m 2 to <30 kg/m 2	1.58	0.81 to 3.07	0.18
≥ 30 kg/m 2	2.58	1.30 to 5.09	0.006

Abbreviations: PSA prostate-specific antigen, ≥2 adverse pathologic features as endpoint

^aDenotes categorical variables. Body mass index, categorical uses BMI <25 kg/m² as reference

Race use White as reference category; “Other” race was dropped from model due to small numbers

Clinical stage, categorical uses (T1; T2a, T2b; >T2c), with T1c as reference category

Clinical Gleason score, categorical (6, 7, ≥8); with 6 as reference category

P values derived from a logistic regression model

Boldfaced values represent statistically significance