Table 1.
Characteristics of subjects
| Study population | Methylation sub-population | |||
|---|---|---|---|---|
| MS+ | MS− | MS+ | MS− | |
| Number of subjects | 1402 | 315 | 25 | 23 |
| Age (years) | 43.9 ± 10.5 | 38.7 ± 9.8*** | 33.9 ± 9.4 | 32.0 ± 7.9 |
| BMI (kg/m2) | 51.8 ± 8.5 | 51.3 ± 8.7 | 52.6 ± 12.7 | 52.3 ± 8.4 |
| Waist girth (cm) | 141.5 ± 17.2 | 135.6 ± 18.5*** | 149.4 ± 24.8 | 143.3 ± 17.1 |
| Fasting glucose (mmol/L) | 6.85 ± 2.43 | 5.11 ± 0.98*** | 6.61 ± 2.79 | 4.95 ± 0.46** |
| Lipid profile (mmol/L) | ||||
| Total-C | 4.67 ± 0.96 | 4.80 ± 0.82* | 4.93 ± 0.75 | 4.47 ± 0.87** |
| LDL-C | 2.65 ± 0.83 | 2.79 ± 0.75** | 2.89 ± 0.65 | 2.68 ± 0.77 |
| HDL-C | 1.18 ± 0.32 | 1.49 ± 0.37*** | 0.96 ± 0.19 | 1.28 ± 0.17*** |
| TG | 1.97 ± 1.12 | 1.17 ± 0.37*** | 2.40 ± 1.30 | 1.12 ± 0.45*** |
| Total-C/HDL-C | 4.18 ± 1.34 | 3.33 ± 0.74*** | 5.32 ± 1.49 | 3.51 ± 0.56*** |
| Blood pressure (mm Hg) | ||||
| SBP | 139 ± 16.7 | 134.7 ± 15.7*** | 145 ± 19.8 | 130.8 ± 13.2** |
| DBP | 84 ± 11.3 | 83.0 ± 10.3 | 89 ± 12.0 | 78.0 ± 9.7** |
Metabolic and anthropometric values in the study population (n = 1720) and in the methylation sub-population (n = 48) of severely obese subjects with and without MS (MS+ and MS−, respectively). Data is expressed as mean ±SD. Asterisks stand for significant differences between MS+ vs. MS− subjects using unpaired Student’s t test (*** P ≤ 0.0001, ** P ≤ 0.01, * P ≤ 0.05, ns: not significant)
BMI body mass index, Total-C total cholesterol, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, TG triglycerides, SBP systolic blood pressure, DBP diastolic blood pressure