Table 3.
Diplotype- and sex-based logistic regression analysis
| All | Men | Women | |||||
|---|---|---|---|---|---|---|---|
| Wald χ2 (P value) | OR (95 % CI) | Wald χ2 (P value) | OR (95 % CI) | Wald χ2 (P value) | OR (95 % CI) | ||
| Total-C | H1/H2 | 5.9 (0.01) | 2.03 (1.59–3.59) | 4.7 (0.03) | 3.00 (1.11–8.06) | 1.7 (0.19) | 1.60 (0.79–3–24) |
| H1/H3 | 1.5 (0.23) | 1.29 (0.85–1.96) | 4.3 (0.04) | 2.10 (1.04–4.25) | 0.0 (0.99) | 1.00 (0.60–1.68) | |
| LDL–C | H1/H2 | 4.6 (0.03) | 1.86 (1.06–3.27) | 6.2 (0.01) | 3.54 (1.31–9.58) | 0.6 (0.45) | 1.31 (0.65–2.62) |
| H1/H3 | 1.9 (0.17) | 1.34 (0.89–2.02) | 7.1 (0.008) | 2.64 (1.29–5.41) | 0.1 (0.80) | 0.94 (0.57–1.55) | |
| TG | H1/H2 | 8.1 (0.004) | 2.19 (1.28–3.74) | 9.8 (0.002) | 7.02 (2.07–13.76) | 1.4 (0.24) | 1.46 (0.78–272) |
| H1/H3 | 3.3 (0.03) | 1.53 (1.03–2.26) | 6.1 (0.01) | 2.43 (1.20–4.93) | 0.3 (0.57) | 1.14 (0.73–1.78) | |
Diplotype-based logistic regression analyses were fitted including sex, age and BMI as confounding factors in the entire population (n = 1720), and including age and BMI when men and women were analyzed separately (n = 537 and n = 1183, respectively). The H3/H3 diplotype was set as the reference group for comparison purposes since it carries wild type alleles of the four meQTLs tested. Significant Wald-tests are shown in italic face (P ≤ 0.05)
OR odds ratio, CI 95 % Wald’s confidence intervals, Total-C total cholesterol, LDL-C low-density lipoprotein cholesterol, TG triglycerides