Table 2.
Comparison of clinical features in patients with Joubert syndrome vs. those with inconclusive MRI findings
| Neuroradiological diagnosis | Joubert syndrome | Inconclusive MRI | T | p |
|---|---|---|---|---|
| Number of patients | 11 | 8 | ||
| Sex | 8 male, 3 female | 3 male, 5 female | ||
| Present age (years) [mean (SD)] | 12.0 (8.3) | 10.4 (6.4) | 0.46 | 0.65 |
| Age at diagnosis of COMA (months) [mean (SD)] | 6.2 (2.7) | 5.4 (2.4) | 0.67 | 0.51 |
| Amelioration of OMA | 100 % (11/11) | 100 % (8/8) | ||
| Unsupported walking at age (months) [mean (SD)] | 28.0 (7.7) | 22.5 (4.3) | 1.82 | 0.09 |
| Cognitive development: | Fisher´s exact test: p = 0.055 | |||
| Normal | 3 | 6 | ||
| Learning disability or intellectual disability | 8 | 2 | ||
Abbreviations: COMA congenital ocular motor apraxia, OMA ocular motor apraxia, SD standard deviation, T T value from T-test for independent variables