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. 2016 Jan 29;8(2):253–263. doi: 10.1080/19420862.2015.1128605

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© 2016 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 2. — Healthy donor T-cell proliferation to IgG1 G1m3-trastuzumab and G1m1,17-trastuzumab. T-cell proliferation was measured from bulk cultures of PBMC on days 5, 6, 7 and 8. Figure shows the maximum stimulation index over the 4 day period. The threshold for positive T-cell proliferation (SI ≥ 1.90, p < 0.05) is indicated by red dotted line. Borderline responses (SI = 1.90-1.95, p < 0.05) are indicated (*). Donors expressing homozygous G1m3 (a and c) and G1m1,17 (b and d) were tested against G1m3-trastuzumab (a and b) and G1m1,17-trastuzumab (c and d)