Table 1.
G1m allotypes |
Amino acid positionsa |
|||
---|---|---|---|---|
CH1 | CH3 | CH1 | CH3 | |
120 | 12 | 14 | ||
(97) | (16) | (18) | ||
214 | 356 | 358 | ||
G1m17 | G1m1 | Lys | Asp | Leu |
aAa | gaT | Ctg | ||
G1m3 | nG1m1 | Arg | Glu | Met |
aGa | gaG | Atg |
Amino acid numbers (bold) are defined according to IMGT unique numbering for C-DOMAIN36; http://www.imgt.org). Numbers in parentheses define exons. Numbers in italics define Eu numbering. 37 The G1m17 allotype (Lys at position 120; CH1) and G1m1 allotype (Asp and Leu at positions 12 and 14, respectively; CH3) are both found on IGHG1*01 and IGHG1*2 alleles. The G1m3 allotype (Arg at position 120; CH1) and nG1m1 (Glu and Met at positions 12 and 14, respectively) are found on IGHG1*03 allele. Upper case letter within 3 letter amino acid code indicates polymorphic nucleotide.