Table 3.
Neuropsychological & quality of life scores at baseline and weeks 12 & 24 of donepezil therapy
| Measure | Baseline | Week 12 | Week 24 | P1 | |||
|---|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | Mean | SD | ||
| Neuropsychological functioning (z-scores) | |||||||
| LDSF | −0.68 | 0.75 | −0.48 | 0.82 | −0.04* | 1.01 | |
| LDSB | −0.62 | 0.52 | −0.64 | 0.79 | −0.43 | 0.78 | |
| DSYM | −1.07 | 1.05 | −0.89 | 1.01 | −0.89 | 0.91 | |
| TMT-A | −1.44 | 1.23 | −1.24 | 1.48 | −1.18 | 1.05 | |
| TMT-B | −1.55 | 1.03 | −1.54 | 1.05 | −1.74 | 0.97 | |
| BTA | −1.76 | 1.08 | −1.67 | 1.10 | −1.68 | 1.38 | |
| HVLT-R | |||||||
| HVLT-L | −1.87 | 0.93 | −2.25 | 1.30 | −1.87 | 1.00 | |
| HVLT-D | −1.43 | 1.23 | −2.15* | 0.81 | −1.83 | 1.08 | |
| HVLT-DI | −1.37 | 1.22 | −1.48 | 1.02 | −1.44 | 1.30 | |
| BVMT-R | |||||||
| BVMT-L | −1.09 | 1.11 | −0.45* | 1.14 | −1.08 | 1.20 | |
| BVMT-R | −1.14 | 1.17 | −0.42* | 1.37 | −0.81 | 1.39 | |
| BVMT-DI | −0.33 | 0.72 | −0.46 | 0.71 | −0.41 | 0.61 | |
| Quality of life (raw scores) | |||||||
| FACT-Br, total | 129 | 24.2 | 129 | 28.6 | 129 | 29.3 | |
| SWB | 21 | 5.2 | 23 | 4.4 | 23* | 4.3 | |
| FWB | 20 | 4.2 | 19 | 5.5 | 18 | 5.8 | |
| PWB | 22 | 4.4 | 21 | 5.8 | 22 | 4.8 | |
| EWB | 18 | 2.7 | 19 | 3.1 | 18 | 4.0 | |
| BrCS | 49 | 16.7 | 54 | 18.0 | 49 | 14.2 | |
SD = Standard Deviation; LDSF = Longest Digit Span Forward; LDSB = Longest Digit Span Backward; DSYM = Digit Symbol; TMT-A = Trail Making Test, Part A; ; TMT-B = Trail Making Test, Part B; BTA = Brief Test of Attention; HVLT-R = Hopkins Verbal Learning Test - Revised; HVLT- L = Hopkins Verbal Learning Test- Learning; HVLT-D = Hopkins Verbal Learning Test- Delayed Recall; HVLT-DI = Hopkins Verbal Learning Test- Discrimination Index; BVMT-R = Brief Visuospatial Memory Test - Revised; BVMT- L = Brief Visuospatial Memory Test - Learning; BVMT-D = Brief Visuospatial Memory Test–Delayed Recall; BVMT-DI = Brief Visuospatial Memory Test - Discrimination Index. FACT-Br = Functional Assessment of Cancer Therapy-Brain; SWB = Social/Family Well-Being; FWB = Functional Well-Being; PWB = Physical Well-Being; EWB = Emotional Well-Being; BrCS = FACT-Br Brain Cancer Subscale.
P-value from linear mixed model indicating whether overall change from baseline (i.e., taking into account both Week 12 and Week 24 scores) was significantly different from 0, controlling for baseline scores
p < 0.05, significantly different from baseline mean using a two-sided paired t-test.