Table 1.

General characteristics of the sample by frailty status (incident or worsening index)

	Incident frailty (N = 5751)			Worsening index (N = 8022)
	FI < 0.25 (n = 4031 [70.1 %])	FI ≥ 0.25 (n = 1722 [29.9 %])	p value	Not worse (n = 3702 [46 %])	Worse (n = 4320 [53.8 %])	p value
Age, mean (SD)	69.5 (6.7)	71.6 (7.7)	<0.001	70.3 (7.3)	71 (7.4)	<0.001
Women, n (%)	1864 (64.7)	1014 (35.2)	<0.001	2443 (53.7)	2104 (46.2)	<0.001
Married, n (%)	2604 (72.6)	980 (27.3)	<0.001	1941 (41.5)	2729 (58.4)	<0.001
Years in school, mean (SD)	5.6 (4.8)	3.7 (3.7)	<0.001	3.8 (3.7)	5.1 (4.7)	<0.001
Smoking status, n (%)						<0.001
Never smoked	2373 (68.7)	1079 (31.2)	<0.001	2476 (48.9)	2586 (51)
Smoked	1179 (70.3)	496 (29.6)		894 (41.1)	1281 (58.9)
Currently smoke	478 (11.8)	146 (23.4)		332 (42.2)	454 (57.7)
At least one negative event, n (%)	184 (54.4)	154 (45.5)	<0.001	193 (41.9)	267 (58)	0.063
Cognitive impairment, n (%)	1283 (66.8)	635 (33.1)	<0.001	1514 (52.5)	1291 (47.4)	<0.001
Cancer, n (%)	120 (64.5)	66 (35.5)	0.092	146 (50.6)	142 (49.3)	0.115
Type of cancer, n (%)						0.015
Gastrointestinal	12 (63.1)	7 (36.8)	0.557	13 (46.4)	15 (53.5)
Gynaecologic	42 (68.8)	19 (31.1)		61 (62.9)	36 (37.1)
Prostate	21 (60)	14 (40)		15 (32.6)	31 (67.3)
Breast	18 (75)	6 (25)		20 (46.5)	23 (53.4)
Other	27 (57.4)	20 (42.5)		37 (50)	37 (50)
Surgery, n (%)	17 (68)	8 (32)	0.821	29 (64.4)	16 (35.5)	0.014
Chemotherapy, n (%)	6 (46.1)	7 (53.8)	0.151	14 (56)	11 (44)	0.322
Radiotherapy, n (%)	8 (57.1)	6 (42.8)	0.549	13 (52)	12 (48)	0.557
Cancer categories (by time since last cancer diagnosis), n (%)						0.005
Without cancer	3910 (70.2)	1655 (29.7)	0.09	3556 (52.6)	4179 (54)
Cancer more than 10 years ago	54 (70.1)	23 (29.8)		78 (60)	52 (40)
Cancer in the last 10 years	66 (60.5)	43 (39.4)		68 (43)	90 (56.9)

FI frailty index, n number, SD standard deviation