Figure 5.

Non-bonded interactions at the interface of antibody Rb86 and the peptide derived from tau/pS422 from 2 different perspectives a) facing the VL interface, and b) facing the VH interface. From the co-crystallized 15-mer 416–430 of tau, only the segment 419–430 (MVDpSPQLATLAD) was assignable. Hydrogen bonds indicated as green dotted lines, hydrophobic interactions indicated as magenta dotted lines, and electrostatic interactions indicated as orange dotted lines. CDR color coding as described in Fig. 1.