Table 6.
Binding signal median change factor, p-value and number of total and rejected VH-VL pairs (“tot./rej.”) for each of the 3 humanization candidate selection methods.
| Fixed percentage (20%) |
Worst chains (80%/max) |
Worst chain comb. (80%/max) |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| factor | p-value | tot./rej. | factor | p-value | tot./rej. | factor | p-value | tot./rej. | |
| Leave-one-out ABangle predictor | |||||||||
| CD81K04 – ELISA | 3.717 | 1.44e-3 | 130/26 | 2.534 | 8.21e-2 | 130/67 | 3.166 | 2.49e-1 | 130/6 |
| CD81K13 – ELISA | 1.572 | 1.12e-2 | 90/18 | 1.618 | 2.36e-2 | 90/76 | 1.665 | 5.75e-2 | 90/16 |
| Rb86 – BL | 3.110 | 0 | 288/57 | 2.384 | 1.85e-1 | 288/33 | 8.676 | 6.99e-2 | 288/1 |
| Rb86 - t½ | 1.435 | 2.36e-2 | 288/57 | 0.864 | 6.69e-1 | 288/33 | / | / | 288/1 |
| All-knowing ABangle predictor | |||||||||
| CD81K04 – ELISA | 3.857 | 6.70e-4 | 130/26 | 3.279 | 4.04e-3 | 130/76 | 4.667 | 1.24e-1 | 130/7 |
| CD81K13 – ELISA | 1.699 | 4.48e-3 | 90/18 | 1.736 | 3.34e-2 | 90/85 | 1.805 | 2.31e-2 | 90/36 |
| Rb86 – BL | 6.173 | 0 | 288/57 | 5.614 | 3.41e-3 | 288/33 | 8.676 | 3.72e-2 | 288/3 |
| Rb86 - t½ | / | / | 288/57 | / | / | 288/33 | / | / | 288/3 |