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. 2016 Jul 25;9:4473–4481. doi: 10.2147/OTT.S100593

Figure 3.

Figure 3

Downregulated TIPE expression inhibits the growth of BGC823 xenografts tumor in athymic mice.

Notes: Comparison of tumor weight and tumor volume in BGC823 tumor-bearing mice of each group. (A) Weight of mice tumor after 14 days treatment, *P<0.05. (B) Volume of mice tumor treated per day, * P<0.05. (C) Hematoxylin–eosin staining, tumor tissue from nude mice injected with Anti-DR5 ScFv showed sheet necrosis, disappearance of intracellular sructures, and cell sputtering; (a) TIPE shRNA tumor treated with Anti-DR5 ScFv, (b) BGC823 tumor treated with Anti-DR5 ScFv (c) BGC823 tumor treated with normal saline (NS) (400×). (D) TUNEL staining; (a) TIPE shRNA tumor treated with Anti-DR5 ScFv; the arrow indicates the apoptosis cell; (b) BGC823 tumor treated with Anti-DR5 ScFv, (c) BGC823 tumor treated with normal saline (200×). (E) Average optical density of panels in (D). *Represents a significant difference between groups a, b, and c.