Table 6.
Multivariate COX regression analysis of the ten-gene expression levels to predict survival adjusted with the IASLC/ATS/ERS classification in the 91 patients
| Variables | HR (95% CI) | P-value |
|---|---|---|
| Age (≧60 vs <60) | 1.95 (0.95–4.00) | 0.071 |
| Sex (F vs M) | 0.77 (0.36–1.62) | 0.483 |
| Smoking (ever vs never) | 0.39 (0.16–0.92) | 0.032* |
| IASLC/ATS/ERS classification (H vs I vs L) | 3.64 (1.99–6.68) | 2.90E-5* |
| BAG1 (H vs L) | 1.16 (0.50–2.71) | 0.732 |
| BRCA1 (H vs L) | 4.50 (1.64–12.32) | 0.003* |
| CDC6 (H vs L) | 2.55 (0.26–25.45) | 0.426 |
| CDK2AP1 (H vs L) | 0.66 (0.08–5.35) | 0.698 |
| ERBB3 (H vs L) | 3.52 (1.40–8.80) | 0.007* |
| FUT3 (H vs L) | 0.84 (0.42–1.72) | 0.639 |
| IL11 (H vs L) | 2.19 (0.96–5.00) | 0.062 |
| LCK (H vs L) | 0.84 (0.39–1.79) | 0.647 |
| RND3 (H vs L) | 1.68 (0.42–6.76) | 0.465 |
| SH3BGR (H vs L) | 0.81 (0.32–2.10) | 0.668 |
*
Note: P<0.01.
Abbreviations: ATS, American Thoracic Society; CI, confidence interval; ERS, European Respiratory Society; F, female; H, high; I, intermediate; HR, hazard ratio; IASLC, International Association for the Study of Lung Cancer; L, low; M, male; RS10, risk score of ten-gene signature.