Table 4.
Factors associated with overall survival and disease-free survival on multivariate analyses for the entire patient population
| Variable | Overall survival | Disease-free survival | ||||
|---|---|---|---|---|---|---|
| HR | 95 % CI | P value | HR | 95 % CI | P value | |
| Age at PM | 1.03 | 1.01–1.04 | 0.001 | – | – | – |
| CRC pTstage | 1.65 | 1.23–2.2 | 0.001 | 1.22 | 1.0–1.48 | 0.05 |
| CRC pNstage | 1.32 | 1.08–1.61 | 0.006 | 1.19 | 1.03–1.38 | 0.021 |
| Previous HM | 1.79 | 1.22–2.63 | 0.003 | 1.45 | 1.1–1.92 | 0.008 |
| DFI (≥12months)a | 0.68 | 0.47–0.94 | 0.02 | 0.63 | 0.49–0.81 | <0.001 |
| Multiple LM | 2.28 | 1.6–3.24 | <0.001 | 1.66 | 1.27–2.16 | <0.001 |
| Size of largest LMb | 1.06 | 0.94–1.19 | 0.343 | 1.1 | 1.0–1.2 | 0.043 |
| Non-anatomical PMc | 0.63 | 0.45–0.89 | 0.009 | – | – | – |
| VATS | 0.82 | 0.6–1.14 | 0.24 | 0.67 | 0.53–0.85 | 0.001 |
| Adjuvant CTx | 0.58 | 0.42–0.82 | 0.002 | – | – | – |
HR hazard ratio, CI confidence interval, PM pulmonary metastasectomy, CRC colorectal cancer, HM hepatic metastasectomy, pTstage pathologic T stage, pNstage pathologic N stage, DFI disease-free interval, LM lung metastases, VATS video-assisted thoracoscopic surgery, CTx chemotherapy
aDisease-free interval was calculated as the interval between the date of colorectal cancer resection and the date of pulmonary metastasectomy
bThe long-axis diameter of the largest lung metastatic nodule was measured
cNon-anatomical pulmonary resection included precision excision of metastatic nodules or wedge resection