Fig. 4.

Thymocyte respiration in mice treated with sirolimus (Day 4). a One representative from three separate experiments. Mice received intraperitoneal DMSO or sirolimus on Days 0–3. On Day 4, thymic fragments were collected and processed immediately for measuring cellular respiration. The rate of respiration (k, µM O₂ min⁻¹) was the negative of the slope of [O₂] vs. t. The values of k _c (µM O₂ min⁻¹ mg⁻¹) are shown at the bottom of each run. The lines are linear fit. b Summary of all results; the horizontal lines are mean