Fig. 5.

Altered AMPA/NMDA ratio and rectification index of AMPAR-mediated currents in the ACC after the formation of chronic itch. a Left, sample traces of evoked synaptic AMPA and NMDA currents recorded at -70 and +40 mV respectively. Scale bars represent 40 pA and 20 ms. Right, summary data of AMPA/NMDA ratio in control (black, 12 neurons) and DCP (grey, 12 neurons) group. AMPAR-mediated synaptic responses were measured at -70 mV, whereas NMDAR-mediated responses were measured at +40 mV and at a latency where AMPAR responses had fully decayed (60 ms). *p < 0.05. b Left, sample traces of evoked AMPAR-mediated postsynaptic currents at -65 and +35 mV holding potentials. Right, Summary data of rectification of AMPAR-mediate currents in control (black, 11 neurons) and DCP (grey, 18 neurons) group. Scale bars represent 20 pA and 20 ms. **p < 0.01. ACC = anterior cingulate cortex; Ctrl = control; DCP = diphenylcyclopropenone