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. 2016 Jul 29;18:78. doi: 10.1186/s13058-016-0737-x

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Representative immunofluorescence images of CD3 and CD8 in one patient. FOVs were compared between different core biopsies of the same patient. Spatial distribution of CD3+ and CD8+ T cells shows both random distribution of T cells among the various margins between and around epithelial cells and also aggregations of T cells into clusters near tumors