Table 1.
Associations of PODXL expression with clinicopathological factors
| Entire cohort | PODXL neg | PODXL pos | ||
|---|---|---|---|---|
| n (%) | n (%) | n (%) | p-value | |
| 171 (100.0) | 29 (17.0) | 142 (83.0) | ||
| Age | ||||
| ≤70 | 85 (49.7) | 12 (41.4) | 73 (51.4) | 0.416 |
| >70 | 86 (50.3) | 17 (58.6) | 69 (48.6) | |
| Sex | ||||
| Female | 39 (22.8) | 9 (31.0) | 30 (21.1) | 0.330 |
| Male | 132 (77.2) | 20 (69.0) | 112 (78.9) | |
| T stage | ||||
| T1 | 18 (10.5) | 2 (6.9) | 16 (11.3) | 0.637 |
| T2 | 32 (18.7) | 6 (20.7) | 26 (18.3) | |
| T3 | 94 (55.0) | 16 (55.2) | 78 (54.9) | |
| T4 | 27 (15.8) | 5 (17.2) | 22 (15.5) | |
| N stage | ||||
| N0 | 57 (33.3) | 16 (55.2) | 41 (28.9) | 0.006 |
| N1 | 29 (17.0) | 4 (13.8) | 25 (17.6) | |
| N2 | 41 (24.0) | 6 (20.7) | 35 (24.6) | |
| N3 | 44 (25.7) | 3 (10.3) | 41 (28.9) | |
| M stage | ||||
| M0 | 152 (88.9) | 25 (86.2) | 127 (89.4) | 0.535 |
| M1 | 19 (11.1) | 4 (13.8) | 15 (10.6) | |
| R classification | ||||
| R0 | 117 (68.4) | 22 (75.9) | 95 (66.9) | 0.556 |
| R1 | 45 (26.3) | 5 (17.2) | 40 (28.2) | |
| R2 | 9 (5.3) | 2 (6.9) | 7 (4.9) | |
| Differentiation grade | ||||
| Low grade | 8 (4.7) | 4 (13.8) | 4 (2.8) | 0.023 |
| Intermediate grade | 52 (30.4) | 10 (34.5) | 42 (29.6) | |
| High grade | 111 (64.9) | 15 (51.7) | 96 (67.6) | |
| Lauren classification | ||||
| Intestinal | 119 (69.6) | 23 (79.3) | 96 (67.6) | 0.335 |
| Mixed | 9 (5.3) | 0 (0.0) | 9 (6.3) | |
| Diffuse | 43 (25.1) | 6 (20.7) | 37 (26.1) | |
| Location | ||||
| Esophagus + EG junction | 106 (62.0) | 15 (51.7) | 91 (64.1) | 0.217 |
| Stomach | 65 (38.0) | 14 (48.3) | 51 (35.9) | |
R0 = no residual tumor (free resection margins according to pathology report), R1 = possible microscopic residual tumor (narrow or compromised resection margins according to pathology report), R2 = macroscopic residual tumor (according to surgery report)
N1 = metastasis in 1–2 regional lymph nodes, N2 = metastasis in 3–6 regional lymph nodes, N3 = metastasis in 7 or more regional lymph nodes
The dichotomized variable for age is based on the mean/median age, as shown in Additional file 1