Table 1.
Clinicopathological characteristics of colorectal carcinoma patients and HSP70-2 gene and protein expression
| Clinicopathological features | RT-PCR (%) of tissue | IHC (%) of tissue | |
|---|---|---|---|
| All tumors | 156/200 (78) | 156/200 (78) | |
| Adjacent normal cancerous tissues | 0/160 (0) | 0/160 (0) | |
| Tumor stages | |||
| Stage I | 6/8 (75) | 6/8 (75) | |
| Stage II | 29/37 (79) | 29/37 (79) | |
| Early stages (I + II) | 35/45 (78) | 35/45 (78) | |
| Stage III | 82/104 (79) | 82/104 (79) | |
| Stage IV | 39/51 (76) | 39/51 (76) | |
| Late stages (III + IV) | 121/155 (78) | 121/155 (78) | |
| Histologic grades | |||
| Well differentiated | 56/71 (79) | 56/71 (79) | |
| Moderately differentiated | 81/102 (79) | 81/102 (79) | |
| Poorly differentiated | 19/27 (70) | 19/27 (70) | |
| Lymph node involvement | |||
| Positive | 121/155 (78) | 121/155 (78) | |
| Negative | 35/45 (78) | 35/45 (78) | |
| Metastasis | |||
| Positive | 39/51 (76) | 39/51 (76) | |
| Negative | 117/149 (79) | 117/149 (79) | |
| Statistical analysis (p values of different test used in this study) | |||
| Clinicopathological features | Mann-Whitney U-test | Pearson’s χ2 test | Kruskal-Wallis Test |
| RT-PCR/IHC | RT-PCR/IHC | RT-PCR/IHC | |
| ANCT, malignancy | 0.0001* | 0.0001* | - |
| Tumor Stage | |||
| I + II | 0.554 | 0.835 | |
| II + III | 0.152 | 0.952 | |
| III + IV | 0.631 | 0.737 | |
| I + II & III + IV | 0.202 | 0.967 | |
| I, II, III, and IV | - | 0.984 | 0.573 |
| Histological Grade | |||
| WD, MD+ PD | - | 0.587 | 0.008* |
| WD + MD | 0.388 | 0.932 | |
| WD + PD | 0.09 | 0.375 | |
| MD + PD | 0.03* | 0.268 | |
| Lymph Node Positivity | 0.202 | 0.967 | |
| Metastasis Positivity | 0.859 | 0.760 | |
IHC immunohistochemistry, MD moderately differentiated, PD poorly differentiated, WD well differentiated
*p < 0.05, statistically significant
Statistical analysis (p values of different test used in this study)