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Amino acid changes associated with host adaptation
| H1N1 | H3N2 | ||||||
|---|---|---|---|---|---|---|---|
| Protein | Position | Avian | Human | Protein | Position | Avian | Human |
| HA | 6 | F | V | HA | 78 | R | E |
| NA | 46 | P | T | NA | 30 | A | I |
| 74 | L | V | 40 | N | Y | ||
| NP | 100 | R | I,V | 44 | I | S | |
| NS1 | 6 | I | M | NP | 16 | G | D |
| NEP | 6 | I | M | PA-X | 28 | P | L |
| PB1-F2 | 58 | L | - | PA | 28 | P | L |
| PB2 | 588 | A | I | 57 | R | Q | |
| PB2 | 9 | D | N | ||||
| 64 | M | T | |||||
