Table 1.
Demographic, laboratory, hemodynamic, and arterial stiffness parameters; subjects’ questionnaire scores
| CONT | HT | |
|---|---|---|
| N (male:female) | 32 (12:20) | 151 (58:93) |
| Age [year] | 61.1 (55.9–70.5) | 63.7 (57–71) |
| Duration of hypertension [year] | – | 11 (5–18) |
| Diabetes [n (%)] | – | 38 (25.2) |
| Cardiovascular disease [n (%)] | – | 21 (13.9) |
| Current smoker [n (%)] | 3 (9.4) | 22 (14.6) |
| Body height [cm] | 168.8 ± 8.6 | 166.8 ± 8.6 |
| Body weight [kg] | 72.4 ± 12.1 | 79.7 ± 14* |
| BMI [kg/m2] | 24.5 ± 5.4 | 28.6 ± 4.5* |
| Platelet count [G/l] | 239.6 (215–277) | 257 (209.7–303.2) |
| Glucose [mmol/l] | 5.36 (4.88–5.81) | 6.15 (5.11–6.7)* |
| GFR-EPI [ml/min/1.73 m2] | 79.7 (69.5–82.2) | 77.9 (67–90) |
| Uric acid [µmol/l] | 313.7 ± 11.6 | 318.4 ± 6.3 |
| Cholesterol [mmol/l] | 5.57 (4.97-6.05) | 5.18 (4.37- 5.98)* |
| LDL [mmol/l] | 3.46 ± 0.91 | 3.07 ± 1.04 |
| HDL [mmol/l] | 1.68 (1.31–1.98) | 1.40 (1.15–1.61)* |
| Triglyceride [mmol/l] | 1.16 (0.75–1.43) | 1.67 (1.08–2.06)* |
| Regular medication [n (%)] | ||
| ACE inhibitors | – | 93 (61.5) |
| ARBs | – | 34 (22.5) |
| CCBs | – | 67 (44.4) |
| Beta blockers | – | 87 (57.6) |
| Diuretics | – | 68 (45) |
| Antiplatelet drugs | – | 44 (29.1) |
| Statins | 5 (15.7) | 54 (35.7) |
| Alprazolam | – | 23 (15.2) |
| TEMPS-A | ||
| Depressive | 5.9 (4–7) | 7.1 (5–9) |
| Cyclothymic | 2.9 (0–4) | 3.9 (1–6) |
| Hyperthymic | 11.2 ± 4 | 11 (4.2) |
| Irritable | 3.2 (2–4) | 4.3 (2–6) |
| Anxious | 4.1 (1–6) | 6.3 (2–9) |
| BDI | 2.8 (1–4) | 6.3 (3–9)* |
| HAM-A | 3.9 (1–6) | 7.4 (2–10)* |
| Heart rate [1/min] | 72.1 (66.6–78.2) | 72.7 (64.1–77.2) |
| Brachial SBP [Hgmm] | 125.5 ± 9.3 | 133.0 ± 12.3* |
| Brachial DBP [Hgmm] | 72 ± 6.4 | 75 ± 9 |
| Brachial PP [Hgmm] | 51.5 (46.4–56.7) | 56.7 (46.4–63)* |
| Central SBP [Hgmm] | 117 (111.2–122.3) | 124.1 (113.4–131.6)* |
| Central DBP [Hgmm] | 67.1 ± 7 | 69.8 ± 8.2 |
| Central PP [Hgmm] | 49.9 (43.2–54.5) | 54.3 (45.2–61) |
| PP amplification | 1.08 (1.03–1.14) | 1.07 (0.98–1.12) |
| PWV [m/sec] | 8.6 (7.4–9.2) | 9.3 (7.8–10) |
| AIx (%) | 13.2 (5.75–23) | 17.8 (8.5–25.1) |
| Serum BDNF (pg/ml) | 21202.6 ± 6045.5 | 24880 ± 8279* |
Continuous data are presented as mean (SD) or mean (interquartile range)
Categorical parameters are presented as % (n)
BMI body mass index, ARBs angiotensin II receptor blockers, CCBs calcium channel blockers, SBP systolic blood pressure, DBP diastolic blood pressure, PP pulse pressure, PWV pulse wave velocity, AIx augmentation index, TEMPS-A Temperament Evaluation of Memphis, Pisa, Paris and San Diego Autoquestionnaire, BDI Beck depression inventory, HAM-A Hamilton anxiety scale
* p < 0.05