Table 4.
Joint effects of smoking, drinking and MTHFR C677T on pancreatic cancer risk
| C677T Genotype | Smoking | Case patients | Control subjects | OR (95 % CI) |
|---|---|---|---|---|
| CC + CT | Never | 109 | 152 | 1.00 |
| TT | Never | 36 | 50 | 1.04 (0.62-1.73) |
| CC + CT | Ever | 179 | 166 | 1.69 (1.13-2.54) |
| TT | Ever | 36 | 32 | 1.94 (1.05-3.57) |
| P for interaction = 0.79 | ||||
| Drinking | Case patients | Control subjects | OR* (95 % CI) | |
| CC + CT | Never | 105 | 120 | 1.00 |
| TT | Never | 29 | 27 | 1.33 (0.72-2.45) |
| CC + CT | Ever | 183 | 198 | 1.10 (0.75-1.61) |
| TT | Ever | 43 | 55 | 1.05 (0.62-1.78) |
| P for interaction = 0.38 |
OR odds ratio, CI confidence interval
*OR was adjusted for age, sex, body mass index, cigarette smoking and history of diabetes