Skip to main content
. Author manuscript; available in PMC: 2016 Jul 29.
Published in final edited form as: J Pediatr Gastroenterol Nutr. 2013 Oct;57(4):438–443. doi: 10.1097/MPG.0b013e31829ef4b4

Figure 1.

Figure 1

Mitochondrial DNA content in hepatic failure. mtDNA depletion was not seen in patients with hepatic failure of non-mitochondrial etiology, although a small reduction in mtDNA was seen in patients with progressive familial intrahepatic cholestasis type 1 (PFIC1), Alagille syndrome (Alagille), Wilson disease (Wilson), and tyrosinemia type 1 (Tyrosinemia). Conversely, liver tissue from patients with two mutations in POLG, MPV17, DGUOK, and TK2 show marked mtDNA depletion, with mtDNA content less than 25% of the mean value for normal controls.