Table 2.
Demographics, Mitochondrial copy number in Liver obtained from individuals with acute liver failure is detailed with mutations detected in DGUOK and POLG.
| Category | Agent | Race | Age (Years) | Gender | dCT | POLG | DGUOK |
|---|---|---|---|---|---|---|---|
| Unknown | C | 12 | M | 6.35 | c.3199T>A (p.S1067T) |
c.494A>T (p.E165V) |
|
| Unknown | C | 3.5 | M | 6.84 | |||
| Unknown | H | 5 | M | 7.05 | |||
| Unknown | C | 7 | M | 7.16 | |||
| Unknown | U | 5 | 7.20 | ||||
| Unknown | U | 13 | F | 7.21 | |||
| Unknown | U | 2.2 | 7.34 | ||||
| Unknown | A | 38 | M | 7.46 | |||
| Unknown | U | 16 | F | 7.56 | c.3428A>AG (p.E1143G) |
||
| Unknown | C | 7 | M | 7.70 | c.1760C>T (p.P587PL) c.752C>T (p.T251I) |
||
| Unknown | A | 42 | F | 7.74 | |||
| Unknown | U | 2.2 | M | 7.74 | c.509A>G (p.Q170R) |
||
| Unknown | C | 42 | F | 7.82 | |||
| Unknown | U | 55 | F | 7.85 | |||
| Unknown | C | 24 | F | 7.88 | |||
| Unknown | H | 17 | M | 8.03 | |||
| Unknown | C | 62 | M | 8.04 | |||
| Unknown | N | 5.5 | M | 8.17 | |||
| Unknown | U | 60 | 9.61 | c.509A>G (p.Q170R) |
|||
| Drug | Acetaminophen | C | 5.6 | F | * | ||
| Drug | Isoniazid | U | 9.5 | M | 6.92 | ||
| Drug | Valproic Acid | C | 2.9 | F | 7.24 | c.1399G>A (p.A467T) |
|
| Drug | Herbal Infusion | A | 38 | F | 7.77 | ||
| Drug | Acetaminophen | C | 48 | F | 7.85 | ||
| Drug | Acetaminophen | C | 34 | M | 8.42 | ||
| Drug | Acetaminophen | U | 35 | F | 8.52 | ||
| Drug | Carbon Terachloride | C | 31 | F | 8.58 | ||
| Drug | Acetaminophen | C | 32 | F | 8.59 | ||
| Drug | Isoniazid | C | 53 | M | 8.85 | c.509A>G (p.Q170R) |
|
| Drug | Acetaminophen | N | 39 | F | 8.88 | ||
| Drug | Valproic Acid | C | 16 | F | 9.36 | ||
| Drug | Acetaminophen | U | 15 | M | 9.41 | ||
| Drug | Acetaminophen | C | 29 | F | 9.43 | ||
| Drug | Acetaminophen | C | 60 | F | 9.66 | * | |
| Drug | Acetaminophen | C | 41 | F | 9.75 | ||
| Viral | ND | B | 26 | F | 4.91 | ||
| Viral | Hepatitis A | N | 14 | M | 6.58 | ||
| Viral | ND | C | 39 | M | 7.04 | ||
| Viral | Hepatitis A | U | 26 | F | 7.44 | ||
| Viral | ND | C | 29 | F | 7.55 | ||
| Viral | Hepatitis A | C | 1.8 | M | 7.65 | ||
| Viral | Influenza | C | 1.9 | M | 7.93 | ||
| Viral | Hepatitis A | C | 24 | F | 8.35 | ||
| Viral | ND | A | 39 | M | 8.47 | ||
| Viral | ND | A | 39 | M | 8.47 |
Key:
Race: A = African American, B= Asian/Pacific Islander C= White Non-Hispanic, N= Native American H= White Hispanic, U= Unknown
Agent: ND= Not Documented
*
Insufficient quantity or quality of DNA