Table 1.
Inclusion criteria (all criteria must apply): • Women with a BRCA1 or BRCA2 germline mutation • Age over 18 years • Written informed consent |
Exclusion criteria: • Ongoing chemo- or radiation therapy (recruitment is possible 6 weeks after completing therapy) • Metastatic tumor disease • Expectancy of life <3 years • Limited cardiovascular and lung diseases (unstable CHC, heart failure stage IV, chronic obstructive pulmonary disease GOLD IV, maximal blood pressure at rest >160/100 mmHg) • Significant orthopedic problems not allowing exercise • Serious diseases not allowing a participation in group interventions (e.g., psychiatric or internal ailment) • Karnofsky index <60 % • Women with an exercise capacity <50 watts • Food allergies not allowing consumption of a Mediterranean dietary pattern • Vegans • BMI <15 kg/m2 • Pregnancy • Insufficient knowledge of the German language • Lack of compliance • Current participation in other lifestyle intervention trials |
CHC Coronary Heart Condition