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. 2016 Feb 24;8(3):585–592. doi: 10.1080/19420862.2016.1141160

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© 2016 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 3. — Combination versus Bispecific treatment: Influence of receptor density on target and decoy binding. A. Simulation of total concentration bound at tumor cells in a decoy cell scenario with decoy-target cell ratio of 1; B. Simulation of IGF1R concentration bound at decoy cells (decoy-target cell ratio of 1). Simulations were performed with a fold10- lower receptor density for IGF1R compared to EGFR on tumor cells, which resembles BxPC-3 cells. The receptor density on the decoy cells was assumed to be 2-fold higher than the EGFR receptor density on tumor cells which resembles the difference between tumor cells (BxPC-3) and decoy cells (NIH3T3).