Figure 6.
CSL311 inhibits the survival of primary human eosinophils cells following stimulation with βc-signaling cytokines. Eosinophils were pre-treated with CSL311 (▴), anti-IL-5Rα (□, 66.7 nM), anti-IL-3Rα (▵, 66.7 nM), anti-GMRα (◊, 66.7 nM), or anti-IL-5Rα/anti-IL-3Rα/anti-GMRα, (•, 66.7 nM each mAb) before treatment with IL-3/GM-CSF/IL-5, for 72h and cell survival determined. No antibody added (▪). Data from representative experiments are shown, n = 5. All values expressed as mean +SEM. Experiments were repeated at least 4 times with representatives shown.