Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Apr 15;8(4):706–717. doi: 10.1080/19420862.2016.1156828

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2016 Merck Sharp & Dohme Corp.

PMC Copyright notice

Figure 8. — (A) Glycan analysis of mAb H samples from different originator production lots and biosimilar samples from different clones/production batches by the high throughput aqueous UMAG and 2-AB HILIC-UPLC. (B) Fast characterization of the glycosylation pathways using mannosidase inhibitor kifunensine in the cell culture by the aqueous UMAG. Top graph represents glycan profile of mAb H from the control cell culture, and bottom graph shows glycan profiles when kifunensine was present in the culture. The inset plot is included to show mannose 7. Kifunensine completely blocked the process of the normal glycans, and resulted in accumulation of high mannose glycans (Man7-9).