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Grade 3/4 toxicities reported for SN-38 ADCs & irinotecan.
| Irinotecan monotherapy | Labetuzumab govitecan | Sacituzumab govitecan | |
|---|---|---|---|
| Dosing regimen | once weekly 125 mg/m2 | Once weekly 10 mg/kg or twice weekly 6 mg/kg | days 1 and 8 of 21 day cycle 10 mg/kg |
| Neutropenia | 26% | 10% | 24% |
| Febrile neutropenia | 3% | 6% | |
| Diarrhea | 31% | 2% | 3% |
| Leukopenia | 28% | 2% | |
| Anemia | 7% | 3% | 6% |
