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. 2016 Mar 16;8(4):811–827. doi: 10.1080/19420862.2016.1160989

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© 2016 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 4. — Tumor cell binding and IGF-1R phosphorylation inhibition of XGFR*. (A) Competitive FACS analysis of bispecific constructs XGFR and XGFR*, bivalent IGF-1R antibody R1507 and monovalent R1507 Fab fragment on A549 cells with surface expression of IGF-1R and EGFR and (B) TC-71 cells with surface expression of IGF-1R in absence of EGFR. (C) Inhibition of IGF-1R phosphorylation of XGFR, XGFR* and parental control antibody mixture R1507/GA201 in A549 and (D) TC-71 cells. Titration curves in the indicated concentration range and IC50 values are shown.