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Schematic overview of binding determinants of BMP4 and the different anti-BMP4 tested. Existing anti-BMP4 antibodies engage their target via interactions through different domains within BMP4. Whereas C4C4 and C8C8 bind to the BMPR1a binding site, inactive antibodies bind to the pro-domain and weak antibodies bind to certain regions of the mature protein, such as the heparin domain (HD), that do not correspond to the BMPR1a binding site.
