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. Author manuscript; available in PMC: 2016 Jul 29.
Published in final edited form as: Cell Microbiol. 2008 Jun 28;10(10):2067–2077. doi: 10.1111/j.1462-5822.2008.01189.x

Fig. 2. Absence of NOD2 has a limited effect on PnCW-induced inflammatory transcription.

Fig. 2

A. Select inflammatory targets induced by PnCW in control or NOD2-deficient BMDMs. Data for each target mRNA is plotted as the average difference signal intensity. Data are averages from independent (n = 4) Affymetrix arrays performed per genotype and per time. No significant differences (paired t-test) were detected between genotypes. Complete data sets for this experiment have been deposited in the GEO database.

B. Expression of IL-10 target genes is affected in the absence of NOD2 function. Signal intensity for IL-10 (left most in the panel) and selected genes whose expression is dependent, in part, on autocrine-paracrine IL-10 production. *P < 0.05, paired t-test comparing 4 h time points between control and Nod2−/− BMDMs (n = 4).