Fig 5.

A) Impairment of the hind limbs of frogleg rats (bottom two panels) compared to wild type Sprague Dawley rats at 4 months (top two panels). B) Left hind limbs of a wildtype (left) and a frogleg (right) rat. Note the inner rotation and extension of the frogleg rat compared with the normal alignment and orientation of the wild type. Also, note the similarity in muscle mass. The cartoon at the bottom of the figure demonstrates the joint alignment and orientation. C) The hind paw of a wild type and a frogleg rat are shown in (left) and (right), respectively. Note the in-turning (pronated) ankles in frogleg with hyperkeratosis of foot pads and toenail overgrowth (arrow), likely related to abnormal or reduced wear.