Table 1.
Histopathologic features of biopsies from transplant patients
| aGVHD-positive | aGVHD-negative | Equivocal | |||
|---|---|---|---|---|---|
| Feature | n (%) TCD/+aGVHD (total n=13) |
n (%) T replete/+aGVHD (total n=38) |
n (%) TCD/− aGVHD (total n=20) |
n (%) T replete/− aGVHD (total n=40) |
|
| Interface Dermatitis | |||||
| Grade 0 | − | NA | 7 (35) | NA | 2 (50) |
| Grade 1 | 3 (23) | 8 (40) | 1 (25) | ||
| Grade 2 | 9 (69) | 5 (25) | − | ||
| Grade 3 | 1 (8) | − | 1 (25) | ||
| Epidermal Thickness | |||||
| Normal | 5 (38) | 7 (18) | 5 (25) | 16 (40) | − |
| Atrophy | 1 (8) | 28 (74) | 2 (10) | 24 (60) | 1 (25) |
| Acanthotic | 7 (54) | 3 (8) | 13 (65) | − | 3 (75) |
| Spongiosis | |||||
| Absent | 6 (46) | 17 (45) | 6 (30) | 32 (80) | 1 (25) |
| Present | 7 (54) | 21 (55) | 14 (70) | 8 (20) | 3 (75) |
| Basal Vacuolization | |||||
| Absent | 1 (8) | 3 (8) | 6 (30) | 9 (22) | 2 (50) |
| Focal | 2 (15) | 16 (42) | 9 (45) | 28 (70) | − |
| Diffuse | 10 (77) | 19 (50) | 5 (25) | 3 (8) | 2 (50) |
| Single necrotic keratinocytes (HPF) | |||||
| Absent | 1 (8) | 5 (13) | 11 (55) | 17 (42) | 3 (75) |
| ≤3 | 8 (61) | 20 (53) | 8 (40) | 21 (52) | − |
| >3 | 4 (31) | 13 (34) | 1 (5) | 2 (5) | 1 (25) |
| Site of necrotic keratinocytes | n=12 | n=33 | n=9 | n=23 | n=1 |
| Basal/suprabasal | 7 (58) | 25 (76) | 9 (100) | 22 (96) | 1 (100) |
| Entire epidermis | 5 (42) | 8 (24) | − | 1 (4) | |
| Adnexal Involvement | |||||
| Absent | 3 (23) | 32 (84) | 11 (55) | 39 (98) | 2 (50) |
| Present | 10 (77) | 6 (16) | 9 (45) | 1 (2) | 2 (50) |
| Minor | 6 (46) | NA | 7 (35) | NA | 1 (25) |
| Major | 4 (31) | NA | 2 (10) | NA | 1 (25) |
| Satellitosis | |||||
| Absent | 3 (23) | 29 (76) | 14 (70) | 40 (100) | 2 (50) |
| Present | 10 (77) | 9 (24) | 6 (30) | − | 2 (50) |
| Inflammatory Infiltrate | |||||
| Absent | − | 1 (3) | − | 24 (60) | − |
| Slight | 10 (77) | 29 (76) | 4 (20) | 16 (40) | 3 (75) |
| Marked | 3 (23) | 8 (21) | 16 (80) | − | 1 (25) |
| Disposition of Inflammatory Infiltrate | n=37 | n=16 | |||
| Perivascular | 7 (54) | 21 (57) | 17 (85) | 14 (88) | 4 (100) |
| Lichenoid* | 6 (46) | 16 (43) | 3 (15) | 2 (12) | − |
| Perivascular +Lichenoid* | 5 (42) | NA | 2 (10) | NA | − |
| Lymphocyte exocytosis | |||||
| Absent | 1 (8) | 24 (63) | 7 (35) | 38 (95) | 2 (50) |
| Present | 12 (92) | 14 (37) | 13 (65) | 2 (5) | 2 (50) |
| Eosinophils | |||||
| Absent | 9 (69) | 37 (97) | 7 (35) | 38 (95) | 2 (50) |
| Present | 4 (31) | 1 (3) | 13 (65) | 2 (5) | 2 (50) |
| Neutrophils | |||||
| Absent | 9 (69) | 38 (100) | 15 (75) | 40 (100) | 1 (25) |
| Present | 4 (31) | − | 5 (25) | − | 3 (75) |
| Plasma cells | |||||
| Absent | 8 (62) | 37 (97) | 13 (65) | 40 (100) | 1 (25) |
| Present | 5 (38) | 1 (3) | 7 (35) | − | 3 (75) |
| Melanophages | |||||
| Absent | − | 24 (63) | 2 (10) | 35 (88) | − |
| Present | 13 (100) | 14 (37) | 18 (90) | 5 (12) | 4 (100) |
| Extravasated erythrocytes | |||||
| Absent | 4 (31) | 33 (87) | 9 (45) | 37 (92) | 1 (25) |
| Present | 9 (69) | 5 (13) | 11 (55) | 3 (8) | 3 (75) |
aGVHD, acute graft versus host disease, TCD, T cell depleted, HPF, high power field