Table 1. Composition, actual drug content, encapsulation efficiency, mean diameter and sphericity coefficient of optimized manufactured by prilling.
| Formulation code | Alginate concentration (%w/v) | P/Alg mass ratio (w/w) | ADC (% ± SD) | EE (% ± SD) | Dried beads diameter (mm ± SD) | SC |
|---|---|---|---|---|---|---|
| F | 2.50 | - | - | - | 2.4 ± 0.15 | 0.93 ± 0.01 |
| F1 | 2.00 | 1:10 | 6.2 ± 0.2 | 67.9 ± 2.0 | 2.4 ± 0.12 | 0.91 ± 0.02 |
| F2 | 2.00 | 1:5 | 11.7 ± 0.6 | 69.9 ± 3.8 | 2.7 ± 0.13 | 0.90 ± 0.02 |
| F3 | 2.25 | 1:10 | 6.6 ± 0.3 | 72.8 ± 3.4 | 2.4 ± 0.12 | 0.90 ± 0.01 |
| F4 | 2.25 | 1:5 | 12.3 ± 0.4 | 73.6 ± 2.3 | 2.5 ± 0.12 | 0.91 ± 0.02 |
| F5 | 2.50 | 1:10 | 6.8 ± 0.2 | 74.3 ± 2.0 | 2.4 ± 0.12 | 0.92 ± 0.02 |
| F6 | 2.50 | 1:5 | 13.1 ± 0.3 | 78.6 ± 2.1 | 2.5 ± 0.12 | 0.90 ± 0.02 |