Fig 7. CLADE annotation supported by domain co-occurrence. Analysis of P. falciparum protein PF3D7_1122900 (PF11_0240).

The protein is 5 251aa long. The list of domains (in various colors and) annotated by various methods is reported on the bottom. A. Comparison of the architectures found by CLADE₂₇ (that is CLADE based on Pfam₂₇ domains) and Pfam₂₇. Six CLADE₂₇ domains, absent in Pfam₂₇, are highlighted by a black dot. B. Two Pfam₂₇ architectures showing domain co-occurrence supporting CLADE₂₇ annotation. C. Comparison of the architectures found by CLADE₂₄ (that is CLADE based on Pfam₂₄ domains), CODD [24], dPUC [26] and Pfam₂₄. Notice that the MORN_2 domain has been predicted by CODD but that it is supported by an extremely high E-value (= 7.5) and no co-occurrence. All other domains have been detected by CLADE₂₄ as well. Eleven CLADE₂₄ domains, absent in Pfam₂₄, are highlighted by a black dot. Some of these domains have been identified by CODD and dPUC also. D. Two Pfam₂₄ architectures showing co-occurrence and supporting CLADE₂₄ annotation. Compare with the Chlamydomonas reinhardtii annotation provided by Pfam₂₇ in B.