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. 2016 Aug 1;27(15):2479–2492. doi: 10.1091/mbc.E16-04-0249

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© 2016 Pifer et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 2: — GRHL2 suppresses the induction of MMP genes and MMP promoters by HGF. (A) GRHL2 suppresses the induction of MMP genes (qPCR analysis; EN, endogenous GRHL2; CE, constitutively expressed GRHL2; KD, GRHL2 shRNA knockdown). (B) GRHL2 suppresses the induction of MMP promoters by HGF. HT1080 cells were cotransfected with either MMP1 or MMP14 promoter-luciferase reporter constructs and GRHL2, E1A, or empty expression vectors. Values represent relative luciferase activity normalized to TK-β-galactosidase control.