TABLE 1:

HGF-induced MMP expression in the absence versus the presence of GRHL2.

Gene regulated by GRHL2	Fold change (shGRHL2+HGF/GRHL2+HGF)	Significance
MMP-1	31.7	Interstitial collagenase, necessary for MDCK tubulogenesis, p300-dependent expression
MMP-9	5.8	Gelatinase B, p300-dependent cancer invasiveness, up-regulated in EMT
MMP-13	15.1	Collagenase 3, necessary for MDCK tubulogenesis, p300-dependent expression
MMP-14	5.82	Membrane-type MMP, involved in EMT regulation and invasiveness phenotype
MMP-19	3.5	Increases invasion in multiple cancers
MMP-24	9.6