Table 3.
Odds ratios (OR) and 95% confidence intervals (95% CIs) for incident tooth loss by vitamin D status determined at study baseline (1997–2000)): The Women’s Health Initiative Osteoporosis and Periodontal Disease (OsteoPerio) Study
| Vitamin D status defined by categories of 25(OH)D (nmol/L) (n=472) | |||
|
Deficient/Inadequate (<50) OR (95% CI) |
Adequate (≥50) OR (95% CI) |
p-for trend* | |
| Any Tooth Loss† | |||
| N outcome/total | 126/156 | 250/316 | |
| Unadjusted model | 1.0 | 0.90 (0.56–1.46) | 0.765 |
| Age adjusted model | 1.0 | 0.93 (0.57–1.51) | 0.515 |
| Multivariable model‡ | 1.0 | 1.07 (0.62–1.85) | 0.111 |
| Tooth Loss due to Periodontal Disease§ | |||
| N outcome/total | 13/43 | 35/101 | |
| Unadjusted model | 1.0 | 1.22 (0.57–2.64) | 0.671 |
| Age adjusted model | 1.0 | 1.33 (0.60–2.96) | 0.368 |
| Multivariable model‡ | 1.0 | 1.61 (0.67–3.89) | 0.099 |
| Tooth Loss due to Caries‖ | |||
| N outcome/total | 113/143 | 215/281 | |
| Unadjusted model | 1.0 | 0.87 (0.53–1.41) | 0.804 |
| Age adjusted model | 1.0 | 0.89 (0.54–1.47) | 0.586 |
| Multivariable model‡ | 1.0 | 1.01 (0.58–1.77) | 0.142 |
| Vitamin D status defined by categories of total vitamin D intake (IU/day) (n=470) | |||
|
< 600 OR (95% CI) |
≥ 600 OR (95% CI) |
p-for trend* | |
| Any Tooth Loss¶ | |||
| N outcome/total | 224/276 | 151/194 | |
| Unadjusted model | 1.0 | 0.82 (0.52–1.28) | 0.292 |
| Age adjusted model | 1.0 | 0.86 (0.54–1.36) | 0.367 |
| Multivariable model‡ | 1.0 | 0.90 (0.56–1.44) | 0.567 |
| Tooth Loss due to Periodontal Disease# | |||
| N outcome/total | 26/78 | 22/65 | |
| Unadjusted model | 1.0 | 1.02 (0.51–2.05) | 0.838 |
| Age adjusted model | 1.0 | 1.35 (0.64–2.86) | 0.566 |
| Multivariable model‡ | 1.0 | 0.99 (0.43–2.28) | 0.956 |
| Tooth Loss due to Caries** | |||
| N outcome/total | 198/250 | 129/172 | |
| Unadjusted model | 1.0 | 0.79 (0.50–1.25) | 0.246 |
| Age adjusted model | 1.0 | 0.82 (0.51–1.31) | 0.304 |
| Multivariable model‡ | 1.0 | 0.87 (0.54–1.42) | 0.534 |
Logistic regression was used to calculate p for linear trend using continuous 25(OH)D plasma concentrations or total vitamin D intake.
There are 472 women in this analysis, of whom 376 had any incident tooth loss (due to periodontal disease, caries, or both), and 96 had no incident tooth loss due to any reasons.
Multivariable model: adjusted for age, annual family income, smoking status, frequency of dental visits, waist circumference and recreational physical activity.
There are 144 women in this analysis, of whom 48 had incident tooth loss due to periodontal disease (with or without incident tooth loss due to caries), and 96 had no incident tooth loss due to any reasons.
There are 424 women in this analysis, of whom 328 had incident tooth loss due to caries and no incident tooth loss due to periodontal disease, and 96 had no incident tooth loss due to any reasons.
There are 470 women in this analysis, of whom 375 had any incident tooth loss (due to periodontal disease, caries, or both), and 95 had no incident tooth loss due to any reasons.
There are 143 women in this analysis, of whom 48 had incident tooth loss due to periodontal disease (with or without incident tooth loss due to caries), and 95 had no incident tooth loss due to any reasons.
There are 422 women in this analysis, of whom 327 had incident tooth loss due to caries and no incident tooth loss due to periodontal disease, and 95 had no incident tooth loss due to any reasons.