Table 2.
Differences in miRNA expression by tumor molecular phenotype with a false discovery rate set at 0.05
| miRNA | % Expressing | Mean Expression | % Expressing | Mean Expression | Siggenes p value | Fold Change (mutated/not mutated) |
|---|---|---|---|---|---|---|
| Colon Cancer | TP53 Not Mutated | TP53 Mutated | ||||
| hsa-let-7b-3p | 10.6 | 2.1 | 15.4 | 4.22 | 0.00148 | 2.01 |
| hsa-let-7d-3p | 8.7 | 2.45 | 14 | 4.45 | 0.00282 | 1.81 |
| hsa-miR-1226-3p | 0.2 | 0.36 | 2.4 | 2.13 | 0.00165 | 5.89 |
| hsa-miR-1227-3p | 4.2 | 1.3 | 7.8 | 2.82 | 0.00174 | 2.17 |
| hsa-miR-124-3p | 20.9 | 1.33 | 15 | 0.85 | 0.01242 | 0.64 |
| hsa-miR-1296 | 3.7 | 0.92 | 7.4 | 2.41 | 0.00154 | 2.61 |
| hsa-miR-133b | 12.4 | 1.47 | 19.4 | 2.34 | 0.00074 | 1.59 |
| hsa-miR-1976 | 0.2 | 0.53 | 2.6 | 9.05 | 0.00059 | 17.07 |
| hsa-miR-3190-5p | 0.3 | 1.32 | 2.6 | 4.61 | 0.00238 | 3.49 |
| hsa-miR-328 | 12.7 | 2.37 | 17.4 | 4.89 | 0.00213 | 2.06 |
| hsa-miR-34b-5p | 2.5 | 3.61 | 1.2 | 1.53 | 0.01979 | 0.42 |
| hsa-miR-3613-3p | 0.3 | 0.42 | 2.4 | 4.7 | 0.00306 | 11.27 |
| hsa-miR-4469 | 27.1 | 1.7 | 20.8 | 1.12 | 0.00334 | 0.66 |
| hsa-miR-449b-3p | 4.5 | 2.71 | 8.8 | 5.04 | 0.0031 | 1.86 |
| hsa-miR-4695-3p | 2.7 | 1.51 | 5.6 | 3.5 | 0.00273 | 2.32 |
| hsa-miR-4700-3p | 13.9 | 2.06 | 9.8 | 1.35 | 0.0479 | 0.65 |
| hsa-miR-4763-5p | 13.6 | 1.54 | 18.2 | 3.03 | 0.00211 | 1.96 |
| hsa-miR-513a-3p | 13.1 | 0.84 | 9.2 | 0.49 | 0.02807 | 0.59 |
| hsa-miR-625-5p | 11.1 | 1.77 | 6.2 | 1.09 | 0.00439 | 0.62 |
| hsa-miR-6509-3p | 0.2 | 0.71 | 2.2 | 4.91 | 0.00289 | 6.88 |
| hsa-miR-6511a-3p | 3.9 | 2.24 | 7.4 | 4.81 | 0.00198 | 2.15 |
| hsa-miR-885-5p | 7.9 | 4.16 | 12.4 | 7.44 | 0.00246 | 1.79 |
| Rectal Cancer | ||||||
| hsa-miR-127-5p | 6.7 | 0.23 | 11.3 | 0.37 | 0.02098 | 1.65 |
| hsa-miR-192-3p | 23.9 | 1.42 | 36.5 | 2.21 | 0.00006 | 1.56 |
| hsa-miR-3180 | 4.8 | 0.86 | 11.8 | 1.54 | 0.00022 | 1.79 |
| hsa-miR-4700-3p | 9.6 | 3.03 | 5.5 | 0.48 | 0.00375 | 0.16 |
| hsa-miR-590-5p | 11.8 | 1.13 | 20.6 | 1.81 | 0.00159 | 1.6 |
| Rectal Cancer | KRAS Not Mutated | KRAS Mutated | ||||
| hsa-miR-192-3p | 32.9 | 2.1 | 21.6 | 1.1 | 0.00009 | 0.53 |
| hsa-miR-196b-5p | 77.9 | 16.36 | 73.4 | 10.54 | 0.00062 | 0.64 |
| hsa-miR-204-3p | 4.7 | 0.4 | 10.8 | 0.67 | 0.01043 | 1.66 |
| hsa-miR-324-5p | 48.6 | 4.37 | 32 | 2.74 | 0.00001 | 0.63 |
| hsa-miR-374b-5p | 38.2 | 6.09 | 30.2 | 3.57 | 0.00127 | 0.59 |
| hsa-miR-4255 | 3.3 | 0.34 | 7.2 | 0.56 | 0.04833 | 1.66 |
| hsa-miR-4290 | 28.7 | 3.92 | 18.5 | 2.48 | 0.00311 | 0.63 |
| hsa-miR-518e-5p | 0.2 | 1.23 | 2.7 | 2.05 | 0.03663 | 1.66 |
| hsa-miR-532-5p | 47.7 | 5.03 | 42.3 | 3.27 | 0.00491 | 0.65 |
| hsa-miR-552 | 13.6 | 4.19 | 6.8 | 2.31 | 0.00009 | 0.55 |
| hsa-miR-652-3p | 25.6 | 1.88 | 17.1 | 1.21 | 0.00323 | 0.64 |
| hsa-miR-660-5p | 14.7 | 3.11 | 7.7 | 2.05 | 0.0002 | 0.66 |
| hsa-miR-7-5p | 54.3 | 6.59 | 45 | 4.44 | 0.0002 | 0.67 |
| Colon Cancer | CpG Island Methylator Phenotype Low | CpG Island Methylator Phenotype High | ||||
| hsa-miR-196a-5p | 66.3 | 6.85 | 50.9 | 4.6 | <0.00001 | 0.67 |
| hsa-miR-196b-5p | 82.7 | 18.03 | 68 | 9.4 | <0.00001 | 0.52 |
| hsa-miR-31-5p | 9.9 | 7.31 | 32.7 | 12.12 | <0.00001 | 1.66 |
| hsa-miR-4267 | 3.7 | 0.59 | 7.6 | 1.37 | 0.026 | 2.33 |
| hsa-miR-513a-3p | 10.1 | 0.58 | 15.6 | 0.99 | 0.03441 | 1.71 |
| hsa-miR-548d-5p | 11.4 | 0.97 | 7.3 | 0.38 | 0.00389 | 0.39 |
| hsa-miR-590-5p | 23.6 | 2.28 | 16.4 | 1.14 | 0.0008 | 0.5 |
| hsa-miR-625-5p | 6.6 | 0.96 | 13.8 | 2.33 | 0.00063 | 2.43 |
| Colon Cancer | BRAF Not Mutated | BRAF Mutated | ||||
| hsa-miR-196a-5p | 63.5 | 6.48 | 42.2 | 3.18 | 0.00042 | 0.49 |
| hsa-miR-196b-5p | 79.7 | 16.39 | 67.8 | 7.28 | 0.00027 | 0.44 |