Table 5.

Associations between miRNAs dysregulated for colon and for rectal cancer and colorectal cancer survival

Survival	Original Tumor							P-value
Association	Phenotype	miRNA	% Expressing	25th %ile1	75th %ile1	Hazard Ratio2	(95% Confidence Intervals)	Raw2	Adjusted3
Colon	CIMP and MSI4	hsa-miR-31-5p	14.8	0.00	0.00	1.49	(1.16,  1.91)	0.002	0.01
Colon	MSI	hsa-miR-193b-3p	86.8	1.92	3.40	1.28	(1.14,  1.44)	0.0001	0.009
Colon	MSI	hsa-miR-214-3p	90.9	2.36	3.99	1.26	(1.11,  1.43)	0.0003	0.03
Colon	MSI	hsa-miR-28-5p	21.0	0.00	0.00	1.62	(1.26,  2.08)	0.0002	0.02
Colon	MSI	hsa-miR-99b-5p	47.3	0.00	2.54	1.55	(1.25,  1.92)	<.0001	0.005
Rectal	KRAS	hsa-miR-552	9.7	0.00	0.00	0.47	(0.28,  0.77)	0.003	0.03
Rectal	MSI	hsa-miR-3653	94.8	3.28	4.19	0.80	(0.71,  0.90)	0.0006	0.02
Rectal	MSI	hsa-miR-520e	91.4	3.00	3.68	1.21	(1.07,  1.37)	0.001	0.04
Rectal	MSI	hsa-miR-636	99.4	3.00	3.44	1.25	(1.11,  1.41)	0.0005	0.02
Rectal	TP53	hsa-miR-192-3p	23.1	0.00	1.64	0.65	(0.48,  0.88)	0.005	0.03
Additional Adjustment for MSI
Colon	BRAF	hsa-miR-196b-5p	76.8	1.58	4.24	0.83	(0.71,  0.97)	0.02	0.04
Colon	CIMP and MSI	hsa-miR-31-5p	14.8	0.00	0.00	1.70	(1.32,  2.19)	<.0001	0.004
Colon	MSI	hsa-miR-99b-5p	47.3	0.00	2.54	1.59	(1.28,  1.97)	<.0001	0.003
Rectal	MSI	hsa-miR-636	99.4	3.00	3.44	1.23	(1.09,  1.39)	0.001	0.04
Rectal	TP53	hsa-miR-192-3p	23.1	0.00	1.64	0.65	(0.48,  0.89)	0.007	0.03

¹Expression values for the 25th and 7th are expressed as log2 transformed values that were used in the Cox proportional hazard models

²p values adjusted for age, sex, and AJCC Stage

³Adjusted for multiple comparisons

⁴CIMP=CpG Island Methylator Phenotype and MSI = Microsatellite Instability status