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. Author manuscript; available in PMC: 2017 Jul 28.
Published in final edited form as: Cell. 2016 Jun 29;166(3):755–765. doi: 10.1016/j.cell.2016.05.069

Figure 4. Kaplan-Meier plot of overall survival stratified by CNA-derived signatures.

Figure 4

A survival plot is shown for a consensus of the four best signatures (see Figure S4A and Table S6) identified from analysis of proteins affected in trans by CNAs. Models were trained using a lasso-based Cox proportional hazards model on the samples from PNNL, and shown are the survival curves from these models applied to the non-overlapping data from the JHU analysis, with the up (red; above the median) and down (blue, below the median) signatures each representing 45 patients. A vote was taken among the four most predictive signatures, and the results of this vote are shown. Probability of death is shown on the y-axis vs. survival time in years on the x-axis. Shaded ribbons denote 95% confidence intervals.