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. Author manuscript; available in PMC: 2017 Jul 28.
Published in final edited form as: Cell. 2016 Jun 29;166(3):755–765. doi: 10.1016/j.cell.2016.05.069

Figure 6. DDN analysis and lysine-acetylation analysis between HRD and non-HRD patients.

Figure 6

DDN analysis revealed a sub-network of proteins that displayed distinct co-expression patterns between HRD and non-HRD patients, where purple connections indicate protein correlations that exist only in HRD samples and blue connections indicate protein correlations that exist only in non-HRD patients. The links between the nodes are drawn with two different thickness indicative of whether the connections meet the significance threshold of 0.05 (light lines) or 0.01 (bold lines). Proteins with blue dotted circles are known to be involved in histone acetylation or deacetylation. Further, identification and quantitation of lysine-acetylated peptides in global proteomics data showed that acetylation level at K12 and K16 of histone H4 are significantly different between HRD and non-HRD samples, suggesting a role of histone H4 acetylation (together with HDAC1) in modulating the choice of DSB repair mechanisms.