Figure 6. Lineage reconstruction for adult zebrafish ADR1.

Unique alleles sequenced from adult zebrafish organs can be related to one another using a maximum parsimony approach implemented in the PHYLIP Mix package (see Materials and Methods and fig. S4B). For reasons of space, we show a tree reconstructed from the 601 ADR1 alleles observed at least five times in individual organs. Eight major clades are displayed with colored nodes, each defined by ‘ancestral’ edits that are shared by all alleles assigned to that clade (shown in Fig. 7A). Editing patterns in individual alleles are represented as shown previously. Alleles observed in multiple organs are plotted on separate lines per organ and are connected with stippled branches. Two sets of bars outside the alleles identify the organ in which the allele was observed and the proportion of cells in that organ represented by that allele (log scale).