Fig. 2.

Loss of AQP2 from the resistant lines. a Roche-454 sequencing reads generated from genomic DNA of STIB900-P and STIB900-M mapped to the reference sequence of STIB900 as visualized with BamView [59]. The gene AQP2 is missing in both STIB900-P and STIB900-M. b The tandem nature of the AQP2/AQP3 locus on chromosome 10 as illustrated by a dot plot of the STIB900 reference sequence from (a) on the x axis vs. the sequence of AQP3 on the y axis (made with GEPARD [60] and a word length of 10). The genes AQP2 and AQP3 are highly similar (82 % global identity) as depicted by the diagonal on the right