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. 2016 Mar 14;73(17):3387–3400. doi: 10.1007/s00018-016-2173-6

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 5 — AT1/AQP2 double knock-out in T. brucei. In vitro drug sensitivities were determined for pentamidine and melarsoprol on parental 2T1 cells, 2T1-aqp2 ^−/−, 2T1-aqp2 ^−/−-AT1 ^+/−, and 2T1-aqp2 ^−/−-at1 ^−/−. Bars are the average IC₅₀ of at least four independent experiments, each performed in triplicate. Error bars indicate the standard error of the mean