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. 2016 Apr 21;73(17):3221–3247. doi: 10.1007/s00018-016-2223-0

Fig. 10.

Fig. 10

Role of Nrf2/HO-1 in tumor initiation and progression. Both Nrf2 and HO-1 may decrease tumor initiation through the detoxification and ROS scavenging mechanisms. On the other hand, this cytoprotective system exerts stimulatory effect on the progression of tumors mostly due to its anti-apoptotic, pro-angiogenic, pro-migratory and modulatory influence on the expression of microRNAs. However, in some tumors the opposite, inhibitory effect on progression of tumors have been reported