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. 2016 Jun 1;157(8):3140–3148. doi: 10.1210/en.2016-1243

Figure 1.

Figure 1.

Effect of Ang II on mTORC1 activity in hypothalamic GT1–7 cells. A, Ang II (100nM) increased phosphorylated S6K (p-S6K) in a time-dependent manner in GT1–7 cells transfected with AT1aR (closed columns). Ang II had no effect on p-S6K at 15 minutes without the transfection (white columns). B, Effect of losartan (Los) on Ang II-induced activation of mTORC1 pathway. In AT1aR-transfected GT1–7 cells, losartan blocked the increase in phosphorylation of S6K by Ang II. Values are mean ± SEM, n = 3–4; *, P < .05 vs baseline (0 min) (A) and all other groups (B), one-way ANOVA.