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. 2016 Jun 1;157(8):3140–3148. doi: 10.1210/en.2016-1243

Figure 7.

Figure 7.

Effect of rapamycin on SBP and water intake in sRA mice. A, Daily ICV treatment with rapamycin (10 ng/d for 7 d) failed to decrease SBP in sRA mice. B, Daily ICV administration of rapamycin (10 ng/d for 3 d) reduced 24-hour water intake in sRA mice. C, Schematic summarizing the selective role of mTORC1 signaling in the SFO in underlying Ang II-mediated control of water intake vs BP. Values are mean ± SEM, n = 6–20 per group; *, P < .05 vs control groups; †, P < .05 vs all other groups, one-way ANOVA.