Table 1.
Electrophysiological Properties of MSNs in Prepubertal Male and Female Rat AcbC
| Property | Male | Female | Statistics (t/U, P) |
|---|---|---|---|
| Resting membrane potential (mV) | −83.09 ± 1.83 (20) | −86.52 ± 1.16 (21) | 1.60; 0.12 |
| Input resistance (MΩ) | 343.00 ± 50.48 (19) | 247.70 ± 22.60 (21) | 166, 0.37 |
| Time constant of the membrane (ms) | 23.98 ± 2.51 (19) | 19.87 ± 1.40 (20) | 1.45; 0.16 |
| Capacitance (pF) | 79.08 ± 6.50 (20) | 84.99 ± 6.56 (21) | 186; 0.54 |
| Rectified range input resistance (MΩ) | 195.90 ± 21.79 (19) | 152.90 ± 10.93 (20) | 1.79; 0.08 |
| % inward rectification (%) | 62.34 ± 3.09 (20) | 66.10 ± 2.01 (22) | 182; 0.35 |
| Sag index | 0.008 ± 0.002 (20) | 0.007 ± 0.001 (22) | 219; 0.99 |
| AP threshold (mV) | −54.74 ± 1.40 (20) | −56.50 ± 0.88 (21) | 1.08; 0.29 |
| AP amplitude (mV) | 61.11 ± 3.45 (20) | 64.48 ± 3.41 (22) | 0.69; 0.49 |
| AP width (ms) | 2.30 ± 0.14 (20) | 2.23 ± 0.09 (22) | 0.41; 0.69 |
| AHP peak (mV) | −8.14 ± 0.81 (19) | −7.16 ± 0.420 (21) | 1.11; 0.27 |
| AHP time to peak (ms) | 29.19 ± 2.69 (19) | 28.00 ± 1.30 (22) | 0.42; 0.68 |
| Delay to first AP (ms) | 234.20 ± 15.26 (20) | 242.8 ± 12.48 (22) | 0.44, 0.66 |
| Rheobase (nA) | 0.06 ± 0.01 (20) | 0.07 ± 0.01 (22) | 0.43, 0.67 |
| FI slope (Hz/nA) | 231.50 ± 20.22 (17) | 233.55 ± 17.66 (22) | 0.08, 0.94 |
| mEPSC frequency (Hz) | 2.60 ± 0.35 (13) | 4.41 ± 0.68 (10) | 2.52, 0.02 |
| mEPSC amplitude (pA) | 14.52 ± 1.12 (13) | 16.81 ± 0.57 (10) | 1.66, 0.11 |
| mEPSC decay (ms) | 4.20 ± 0.18 (13) | 4.14 ± 0.31 (10) | 0.20, 0.84 |
Values are mean ± SEM. Numbers in parentheses indicate sample size. The sag index is unitless. Significant differences are indicated with bold font. Recordings were made from prepubertal male and female rats that did not receive injections as neonates. AP, action potential; AHP, afterhyperpolarization.